Rejuvenating the Aging Brain Blood Factor!
In rejuvenation research, there have been studies on transfusion of young people’s blood and experiments on injecting animals with the anti-aging hormone “Klotho”.
Now, three interesting papers have been published in Nature, Nature Aging, and Nature Communications on August 16, 2023, that lead to the identification of a factor common to numerous studies on rejuvenation.
[PF4]
Saul Vileda, deputy director of the Bachar Institute on Aging at the University of California, San Francisco, and his team found that platelet factor 4 (PF4), which functions to clot blood in the event of bleeding, restores brain function.
When the team administered PF4 alone to aged mice, the effect was almost identical to that of injections of plasma from young mice, and the aged mice performed better on tests of learning and memory.
The researchers found that PF4 improved the aging immune system and that this may restore cognitive function by reducing inflammation in the brain.
We have 22-month-old mice, the equivalent of humans in their 70s, and PF4 has rejuvenated their abilities to their late 30s and early 40s,” Vileda said. He said.
[Klotho] (anti-aging hormone)
Klotho is a hormone named after Clotho, one of the three goddesses of destiny in Greek mythology.
Dana Duval of the University of California conducted an experiment in which he administered PF4 to mice and found that both old and young mice showed improved learning and memory, indicating that PF4 may also help improve cognitive function in the young brain. Duval also found that mice deficient in PF4 also showed improved cognition in Klotho, indicating that there may be other factors besides PF4 that improve cognitive function.”
Ideally, we should be able to provide multiple treatments for cognitive dysfunction, one of the biggest problems in biomedicine, with minimal side effects and maximum efficacy,” he said. He added.
[The movement]
Tara Walker and her team at the Queensland Brain Institute in Australia found that exercise releases PF4 into the blood of mice, which promotes brain cell renewal and improves cognition.
PF4 is also known as a type of signaling molecule released by exercise. Previous research had shown that it was involved in the improvement of cognitive function with exercise, but this research confirmed that the effect of improving cognitive function with PF4 alone, comparable to that of exercise, confirms that the platelet-derived signaling molecule CXCL4, or PF4, is involved in this mechanism This confirms that the platelet-derived CXCL4, or PF4, is involved in this mechanism.
These results may be useful for improving cognitive function in people who are unable to exercise due to age or brain damage,” said Walker.
Medical science has made remarkable progress in recent years, and we are now living in the “100-year life era,” but it may soon be called the “110-year life era” or “120-year life era.
By Admin|2023-09-05|2023,|